\u5728\u57fa\u56e0\u7814\u7a76\u548c\u5206\u5b50\u751f\u7269\u5b66\u9886\u57df\uff0csil1\u548csil2\u4f5c\u4e3a\u4e24\u4e2a\u91cd\u8981\u7684\u57fa\u56e0\u6216\u86cb\u767d\u8d28\u6807\u8bc6\u7b26\uff0c\u7ecf\u5e38\u88ab\u79d1\u7814\u4eba\u5458\u548c\u4e13\u4e1a\u4eba\u58eb\u63d0\u53ca\u3002<\/p>\n<\/p>\n
\u5c3d\u7ba1\u5b83\u4eec\u7684\u540d\u79f0\u76f8\u4f3c\uff0c\u4f46sil1\u548csil2\u5728\u529f\u80fd\u3001\u7ed3\u6784\u3001\u8868\u8fbe\u6a21\u5f0f\u4ee5\u53ca\u6240\u6d89\u53ca\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/p>\n<\/p>\n
\u672c\u6587\u65e8\u5728\u6df1\u5165\u63a2\u8ba8sil1\u4e0esil2\u4e4b\u95f4\u7684\u6838\u5fc3\u533a\u522b\uff0c\u5e2e\u52a9\u8bfb\u8005\u5168\u9762\u7406\u89e3\u8fd9\u4e24\u4e2a\u5173\u952e\u5206\u5b50\u7684\u72ec\u7279\u89d2\u8272\u53ca\u5176\u5728\u751f\u547d\u6d3b\u52a8\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/p>\n
\u4e00\u3001\u57fa\u672c\u5b9a\u4e49\u4e0e\u5206\u5b50\u7279\u6027<\/strong><\/p>\n \u9996\u5148\uff0c\u4ece\u57fa\u672c\u5b9a\u4e49\u6765\u770b\uff0csil1\u901a\u5e38\u6307\u7684\u662fBIP\u5171 chaperone SIL1\uff0c\u8fd9\u662f\u4e00\u79cd\u5728\u5185\u8d28\u7f51\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002<\/p>\n<\/p>\n \u5b83\u4f5c\u4e3a\u5206\u5b50\u4f34\u4fa3BIP\uff08\u7ed3\u5408\u514d\u75ab\u7403\u86cb\u767d\u86cb\u767d\uff09\u7684\u6838\u82f7\u9178\u4ea4\u6362\u56e0\u5b50\uff0c\u534f\u52a9\u86cb\u767d\u8d28\u7684\u6b63\u786e\u6298\u53e0\u548c\u7ec4\u88c5\uff0c\u9632\u6b62\u9519\u8bef\u6298\u53e0\u86cb\u767d\u7684\u79ef\u7d2f\u3002<\/p>\n<\/p>\n sil1\u7684\u7a81\u53d8\u4e0e\u4eba\u7c7b\u9057\u4f20\u6027\u75be\u75c5Marinesco-Sj\u00f6gren\u7efc\u5408\u5f81\u76f8\u5173\uff0c\u8be5\u75be\u75c5\u4ee5\u5171\u6d4e\u5931\u8c03\u3001\u767d\u5185\u969c\u548c\u667a\u529b\u969c\u788d\u4e3a\u4e3b\u8981\u7279\u5f81\u3002<\/p>\n<\/p>\n \u76f8\u6bd4\u4e4b\u4e0b\uff0csil2\u53ef\u80fd\u6307\u4ee3\u4e0d\u540c\u7684\u751f\u7269\u5b66\u5b9e\u4f53\uff0c\u5177\u4f53\u53d6\u51b3\u4e8e\u4e0a\u4e0b\u6587\u3002<\/p>\n<\/p>\n \u5728\u67d0\u4e9b\u7814\u7a76\u4e2d\uff0csil2\u53ef\u80fd\u662f\u4e00\u4e2a\u57fa\u56e0\u7b26\u53f7\u6216\u522b\u540d\uff0c\u4f8b\u5982\u4e0e\u6c89\u9ed8\u4fe1\u606f\u8c03\u8282\u6216\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\u76f8\u5173\u7684\u56e0\u5b50\u3002<\/p>\n<\/p>\n \u7136\u800c\uff0c\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0csil2\u5e76\u975e\u4e00\u4e2a\u5e7f\u6cdb\u6807\u51c6\u5316\u6216 universally \u8ba4\u53ef\u7684\u672f\u8bed\uff0c\u5b83\u53ef\u80fd\u5728\u4e0d\u540c\u7269\u79cd\u6216\u7814\u7a76\u80cc\u666f\u4e0b\u6307\u5411\u4e0d\u540c\u5206\u5b50\u3002<\/p>\n<\/p>\n \u4f8b\u5982\uff0c\u5728\u690d\u7269\u6216\u5fae\u751f\u7269\u4e2d\uff0csil2\u53ef\u80fd\u6d89\u53ca\u80c1\u8feb\u54cd\u5e94\u6216\u4ee3\u8c22\u8c03\u63a7\u3002<\/p>\n<\/p>\n \u56e0\u6b64\uff0c\u5728\u8ba8\u8bbasil2\u65f6\uff0c\u5fc5\u987b\u660e\u786e\u5176\u5177\u4f53\u80cc\u666f\uff0c\u4ee5\u907f\u514d\u6df7\u6dc6\u3002<\/p>\n<\/p>\n \u4e8c\u3001\u529f\u80fd\u673a\u5236\u4e0e\u751f\u7269\u5b66\u89d2\u8272<\/strong><\/p>\n \u5728\u529f\u80fd\u5c42\u9762\uff0csil1\u7684\u6838\u5fc3\u4f5c\u7528\u96c6\u4e2d\u4e8e\u5185\u8d28\u7f51\u86cb\u767d\u8d28\u8d28\u91cf\u63a7\u5236\u3002<\/p>\n<\/p>\n \u901a\u8fc7\u4fc3\u8fdbBIP\u4eceADP\u7ed3\u5408\u72b6\u6001\u5411ATP\u7ed3\u5408\u72b6\u6001\u7684\u8f6c\u6362\uff0csil1\u786e\u4fddBIP\u80fd\u591f\u6301\u7eed\u53c2\u4e0e\u65b0\u751f\u80bd\u94fe\u7684\u6298\u53e0\u8fc7\u7a0b\uff0c\u4ece\u800c\u7ef4\u6301\u7ec6\u80de\u7a33\u6001\u3002<\/p>\n<\/p>\n \u8fd9\u79cd\u529f\u80fd\u5bf9\u795e\u7ecf\u5143\u548c\u5206\u6ccc\u7ec6\u80de\u5c24\u4e3a\u91cd\u8981\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u7ec6\u80de\u7c7b\u578b heavily \u4f9d\u8d56\u9ad8\u6548\u86cb\u767d\u8d28\u5408\u6210\u3002<\/p>\n<\/p>\n sil1\u7f3a\u9677\u4f1a\u5bfc\u81f4\u5185\u8d28\u7f51\u5e94\u6fc0\u52a0\u5267\uff0c\u89e6\u53d1\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\uff0c\u751a\u81f3\u5f15\u53d1\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<\/p>\n \u53e6\u4e00\u65b9\u9762\uff0csil2\u7684\u529f\u80fd\u5219\u66f4\u52a0\u591a\u6837\u5316\u548c\u8bed\u5883\u4f9d\u8d56\u3002<\/p>\n<\/p>\n \u5982\u679csil2\u6307\u7684\u662f\u67d0\u4e2a\u7279\u5b9a\u57fa\u56e0\uff08\u5982\u5728\u67d0\u4e9b\u6a21\u5f0f\u751f\u7269\u4e2d\u7684\u540c\u6e90\u7269\uff09\uff0c\u5b83\u53ef\u80fd\u53c2\u4e0e\u67d3\u8272\u8d28\u91cd\u5851\u3001\u57fa\u56e0\u6c89\u9ed8\u6216\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u3002<\/p>\n<\/p>\n \u4f8b\u5982\uff0c\u5728\u9175\u6bcd\u6216\u679c\u8747\u4e2d\uff0csil2\u7c7b\u56e0\u5b50\u53ef\u80fd\u4f5c\u4e3a\u8f6c\u5f55\u6291\u5236\u5b50\uff0c\u5f71\u54cd\u53d1\u80b2\u6216\u73af\u5883\u9002\u5e94\u3002<\/p>\n<\/p>\n \u6b64\u5916\uff0csil2\u8fd8\u53ef\u80fd\u6d89\u53ca\u514d\u75ab\u54cd\u5e94\u6216\u764c\u75c7\u901a\u8def\uff0c\u4f46\u5176\u5177\u4f53\u673a\u5236\u5f80\u5f80\u9700\u8981\u7ed3\u5408\u5b9e\u9a8c\u6570\u636e\u6765\u786e\u8ba4\u3002<\/p>\n<\/p>\n \u603b\u4f53\u800c\u8a00\uff0csil1\u7684\u529f\u80fd\u8f83\u4e3a\u660e\u786e\u548c\u4fdd\u5b88\uff0c\u800csil2\u5219\u53ef\u80fd\u5c55\u73b0\u51fa\u7269\u79cd\u7279\u5f02\u6027\u6216\u529f\u80fd\u53ef\u5851\u6027\u3002<\/p>\n<\/p>\n \u4e09\u3001\u8868\u8fbe\u6a21\u5f0f\u4e0e\u7ec4\u7ec7\u5206\u5e03<\/strong><\/p>\n \u8868\u8fbe\u6a21\u5f0f\u662f\u533a\u5206sil1\u548csil2\u7684\u53e6\u4e00\u91cd\u8981\u65b9\u9762\u3002<\/p>\n<\/p>\n sil1\u5728\u591a\u79cd\u7ec4\u7ec7\u4e2d\u5e7f\u6cdb\u8868\u8fbe\uff0c\u4f46\u5c24\u5176\u5728\u9ad8\u5206\u6ccc\u6d3b\u6027\u7684\u7ec6\u80de\u4e2d\u4e30\u5ea6\u8f83\u9ad8\uff0c\u5982\u80f0\u817a\u7ec6\u80de\u3001\u809d\u7ec6\u80de\u548c\u795e\u7ecf\u5143\u3002<\/p>\n<\/p>\n \u8fd9\u79cd\u8868\u8fbe\u6a21\u5f0f\u4e0e\u5176\u5728\u86cb\u767d\u8d28\u6298\u53e0\u4e2d\u7684\u7ba1\u5bb6\u529f\u80fd\u4e00\u81f4\u3002<\/p>\n<\/p>\n \u7814\u7a76\u8868\u660e\uff0csil1\u7684\u8868\u8fbe\u53d7\u5185\u8d28\u7f51\u5e94\u6fc0\u8c03\u8282\uff0c\u5728\u5e94\u6fc0\u6761\u4ef6\u4e0b\u53ef\u80fd\u4e0a\u8c03\u4ee5\u5e94\u5bf9\u9519\u8bef\u6298\u53e0\u86cb\u767d\u7684\u7d2f\u79ef\u3002<\/p>\n<\/p>\n \u5bf9\u4e8esil2\uff0c\u5176\u8868\u8fbe\u6a21\u5f0f\u5219\u56e0\u5177\u4f53\u5b9a\u4e49\u800c\u5f02\u3002<\/p>\n<\/p>\n \u5982\u679csil2\u4e0e\u6c89\u9ed8\u6216\u9632\u5fa1\u673a\u5236\u76f8\u5173\uff0c\u5b83\u53ef\u80fd\u5728\u7279\u5b9a\u7ec4\u7ec7\uff08\u5982\u751f\u6b96\u7ec6\u80de\u6216\u514d\u75ab\u5668\u5b98\uff09\u4e2d\u4f18\u5148\u8868\u8fbe\u3002<\/p>\n<\/p>\n \u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0csil2\u7684\u8868\u8fbe\u53ef\u80fd\u53d7\u53d1\u80b2\u9636\u6bb5\u6216\u5916\u90e8\u523a\u6fc0\uff08\u5982\u75c5\u539f\u4f53\u611f\u67d3\uff09\u7684\u5f3a\u70c8\u5f71\u54cd\u3002<\/p>\n<\/p>\n \u56e0\u6b64\uff0c\u7f3a\u4e4f\u7edf\u4e00\u80cc\u666f\u65f6\uff0c\u6cdb\u6cdb\u8ba8\u8bbasil2\u7684\u8868\u8fbe\u53ef\u80fd\u5bfc\u81f4\u8bef\u5bfc\u6027\u7ed3\u8bba\u3002<\/p>\n<\/p>\n \u56db\u3001\u4e34\u5e8a\u4e0e\u75c5\u7406\u5b66\u5173\u8054<\/strong><\/p>\n \u4ece\u75be\u75c5\u5173\u8054\u89d2\u5ea6\u770b\uff0csil1\u4e0e\u660e\u786e\u7684\u4eba\u7c7b\u9057\u4f20\u969c\u788d\u76f4\u63a5\u76f8\u5173\u3002<\/p>\n<\/p>\n \u5982\u524d\u6240\u8ff0\uff0cMarinesco-Sj\u00f6gren\u7efc\u5408\u5f81\u7531sil1\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\uff0c\u60a3\u8005\u8868\u73b0\u51fa\u591a\u7cfb\u7edf\u75c7\u72b6\uff0c\u5305\u62ec\u808c\u8089\u65e0\u529b\u3001\u795e\u7ecf\u7cfb\u7edf\u9000\u884c\u548c\u767d\u5185\u969c\u3002<\/p>\n<\/p>\n \u8fd9\u51f8\u663e\u4e86sil1\u5728\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\u4e2d\u7684\u975e\u5197\u4f59\u4f5c\u7528\u3002<\/p>\n<\/p>\n \u9488\u5bf9sil1\u7684\u7814\u7a76\u4e0d\u4ec5\u6709\u52a9\u4e8e\u7406\u89e3\u75be\u75c5\u673a\u7406\uff0c\u8fd8\u4e3a\u6cbb\u7597\u5f00\u53d1\u63d0\u4f9b\u4e86\u9776\u70b9\u3002<\/p>\n<\/p>\n \u76f8\u53cd\uff0csil2\u7684\u4e34\u5e8a\u610f\u4e49\u53ef\u80fd\u66f4\u4e3a\u95f4\u63a5\u6216\u60c5\u5883\u5316\u3002<\/p>\n<\/p>\n \u5982\u679csil2\u6d89\u53ca\u764c\u75c7\u6216\u514d\u75ab\u75be\u75c5\uff0c\u5b83\u53ef\u80fd\u4f5c\u4e3a\u751f\u7269\u6807\u5fd7\u7269\u6216\u6cbb\u7597\u5019\u9009\u3002<\/p>\n<\/p>\n \u4f8b\u5982\uff0c\u5728\u67d0\u4e9b\u80bf\u7624\u7c7b\u578b\u4e2d\uff0csil2\u540c\u6e90\u7269\u7684\u5f02\u5e38\u8868\u8fbe\u53ef\u80fd\u4e0e\u9884\u540e\u76f8\u5173\u3002<\/p>\n<\/p>\n \u7136\u800c\uff0c\u7531\u4e8e\u672f\u8bed\u4e0d\u4e00\u81f4\uff0c\u8fd9\u7c7b\u5173\u8054\u9700\u8981\u8c28\u614e\u9a8c\u8bc1\uff0c\u907f\u514d\u8fc7\u5ea6\u89e3\u8bfb\u3002<\/p>\n<\/p>\n \u4e94\u3001\u7814\u7a76\u5de5\u5177\u4e0e\u5b9e\u9a8c\u65b9\u6cd5<\/strong><\/p>\n \u5728\u7814\u7a76\u5b9e\u8df5\u4e2d\uff0csil1\u548csil2\u7684 investigation \u5f80\u5f80\u91c7\u7528\u4e0d\u540c\u5de5\u5177\u3002<\/p>\n<\/p>\n \u5bf9\u4e8esil1\uff0c\u5df2\u6709\u6297\u4f53\u3001\u6572\u9664\u5c0f\u9f20\u6a21\u578b\u548c\u7ec6\u80de\u7cfb\u5e7f\u6cdb\u53ef\u7528\uff0c facilitating \u529f\u80fd\u4e27\u5931\u548c\u83b7\u5f97\u6027\u7814\u7a76\u3002<\/p>\n<\/p>\n \u8fd9\u4e9b\u5de5\u5177\u5e2e\u52a9\u63ed\u793a\u4e86sil1\u5728\u53d1\u80b2\u548c\u75be\u75c5\u4e2d\u7684\u5173\u952e\u6027\u3002<\/p>\n<\/p>\n \u5bf9\u4e8esil2\uff0c\u7814\u7a76\u5de5\u5177\u53ef\u80fd\u53d6\u51b3\u4e8e\u5176\u5177\u4f53 identity\u3002<\/p>\n<\/p>\n \u5982\u679csil2\u662f\u4e00\u4e2a\u8f83\u65b0\u6216 less \u7279\u5f81\u7684\u56e0\u5b50\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u80fd\u9700\u4f9d\u8d56\u57fa\u56e0\u7f16\u8f91\u3001RNA\u5e72\u6270\u6216\u751f\u7269\u4fe1\u606f\u5b66\u9884\u6d4b\u6765\u63a2\u7d22\u5176\u529f\u80fd\u3002<\/p>\n<\/p>\n \u8fd9\u79cd\u5dee\u5f02\u53cd\u6620\u4e86\u4e24\u8005\u5728\u79d1\u5b66\u6587\u732e\u4e2d\u7684\u6210\u719f\u5ea6\u4e0d\u540c\uff1asil1\u662f well-established \u5206\u5b50\uff0c\u800csil2\u53ef\u80fd\u4ecd\u5904\u4e8e\u8868\u5f81\u9636\u6bb5\u3002<\/p>\n<\/p>\n \u516d\u3001\u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/p>\n \u7efc\u4e0a\u6240\u8ff0\uff0csil1\u548csil2\u867d\u7136\u540d\u79f0\u76f8\u4f3c\uff0c\u4f46\u5b83\u4eec\u5728\u751f\u7269\u5b66\u4e2d\u4ee3\u8868 distinct \u5b9e\u4f53\u3002<\/p>\n<\/p>\n sil1\u662f\u4e00\u4e2a\u7279\u5f81\u6e05\u6670\u7684\u5206\u5b50\u4f34\u4fa3\u8f85\u52a9\u56e0\u5b50\uff0c\u4e3b\u8981\u4f5c\u7528\u4e8e\u5185\u8d28\u7f51\uff0c\u4e0e\u9057\u4f20\u75be\u75c5\u7d27\u5bc6\u5173\u8054\u3002<\/p>\n<\/p>\n \u800csil2\u662f\u4e00\u4e2a\u8bed\u5883\u4f9d\u8d56\u7684\u672f\u8bed\uff0c\u53ef\u80fd\u6307\u5411\u591a\u79cd\u5206\u5b50\uff0c\u529f\u80fd\u6db5\u76d6\u57fa\u56e0\u8c03\u63a7\u3001\u5e94\u6fc0\u54cd\u5e94\u7b49\uff0c\u4f46\u7f3a\u4e4f\u7edf\u4e00\u5b9a\u4e49\u3002<\/p>\n<\/p>\n \u672a\u6765\u7814\u7a76\u5e94\u6ce8\u91cd\u660e\u786esil2\u7684\u5206\u5b50\u8eab\u4efd\uff0c\u5e76\u901a\u8fc7\u6bd4\u8f83\u5206\u6790\u63ed\u793a\u5176\u4e0esil1\u7684\u6f5c\u5728\u76f8\u4e92\u4f5c\u7528\u6216\u534f\u540c\u6548\u5e94\u3002<\/p>\n<\/p>\n \u7406\u89e3\u8fd9\u4e9b\u5dee\u5f02\u4e0d\u4ec5\u6df1\u5316\u6211\u4eec\u5bf9\u7ec6\u80de\u751f\u7269\u5b66\u7684\u8ba4\u8bc6\uff0c\u4e5f\u4e3a\u7cbe\u51c6\u533b\u5b66\u63d0\u4f9b\u57fa\u7840\u3002<\/p>\n<\/p>\n 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